Alexander Khoruts, MD
Alexander Khoruts, MD, a professor of Medicine in the Division of Gastroenterology, Hepatology, and Nutrition, examines the involvement of T cells in the maintenance of immunologic tolerance. Induction of regulatory T cells (Tregs) may be important in treating autoimmune diseases and encourage tolerance to transplanted organs. The two major questions pursued in the laboratory include mechanisms of T cell induction and the role of Tregs in maintaining diversity of the conventional T cell population. Khoruts also investigates the role of intestinal microbiota in gastrointestinal disease. A major effort is currently being developed to identify the intestinal microorganisms that may be protective against Clostridium difficile associated disease. Specifically, research is being conducted to characterize the microbial composition of the colon before and after bacteriotherapy by way of fecal transfer in patients suffering from recurrent or refractory Clostridium difficile infection.