Brian Fife, PhD

Photo of Brian Fife, PhD

Associate Professor of Medicine, Division of Rheumatic and Autoimmune Diseases
Department of Medicine, Medical School
"At the root of autoimmunity lies the most important aspect of immune regulation, the ability to discriminate between self and non-self. This highly selective response is characterized by a complicated set of mechanisms which regulate T lymphocyte activity, and when these mechanisms fail, autoimmune disorders can follow."

Brian Fife, PhD, is an associate professor of Medicine in the Division of Rheumatic and Autoimmune Diseases. His research is focused on understanding the fundamental mechanisms that regulate T lymphocytes during autoimmune disease. Recently, Dr. Fife and his colleagues have generated a powerful treatment protocol to selectively target autoreactive cells. Using this type of approach allows them to re-educate the immune system to selectively silence destructive immune responses. Thus in effect, restore a state of self-tolerance and prevent further tissue destruction. Fife is a member of the Masonic Cancer Center’s Immunology Research Program.