Elizabeth Amin, PhD
Elizabeth Amin, PhD, is an associate professor of Medicinal Chemistry in the College of Pharmacy. Dr. Amin’s NIH/NIAID-funded research program focuses on chemical, biological, radiological, nuclear and explosive (CBRNE) agent mitigation, with anthrax, the ricin toxin, and organophosphate nerve gases such as sarin, soman and VX as primary therapeutic targets. Her main projects involve the design and optimization of small-molecule anthrax toxin lethal factor (LF) inhibitors, and ricin toxin A (RTA) inhibitors, to be used as emergency therapeutics in the event of bioterror attacks, and engineering enzyme active sites to rapidly and effectively hydrolyze fast-acting nerve agents. In addition, Amin is working on the development of new computational techniques in order to facilitate the design of anti-bioterror therapeutics targeting large metal-bearing molecules. Additional teaching and research areas encompass the design and therapeutic effects of central nervous system (CNS) agents including mood-altering drugs.