Karen Hsiao Ashe, MD, PhD

Photo of Karen Hsiao Ashe, MD, PhD

Professor, Department of Neurology
Founding Director, N. Bud Grossman Center for Memory Research and Care
Edmund Wallace and Anne Marie Tulloch Chairs in Neurology and Neuroscience
 "The ultimate goal of our research is to find a way to prevent Alzheimer’s disease from manifesting itself or prevent it from developing at all."

Karen Hsiao Ashe, MD, PhD, a professor in the Department of Neurology, is a pioneer in Alzheimer’s disease research. Ashe has studied the disease for more than 26 years and in her 20 years at the University of Minnesota she has trained more than 40 undergraduate, doctoral and post-doctoral scientists. Ashe has made a commitment in training the next generation of great scientists, in particular developing the careers of translational scientists. Her primary research areas include the genetics of human prion diseases; transgenic models of prion and Alzheimer’s diseases; and the molecular basis of memory loss in Alzheimer’s disease. Ashe’s current research interest involves the discovery of tau mutations that cause neurodegeneration. Ashe created tau transgenic mice to study tau-based mechanisms of memory loss and neurodegeneration. In 2006, Ashe became the founding Director of the N. Bud Grossman Center for Memory Research and Care, a tripartite endeavor encompassing basic, translational and clinical research and care in memory disorders. 

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